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"The best piece of advice that I've received to manage my MS is to take care of myself."

Shiela, MS LifeLines Ambassador

Living with RRMS since 2002

Taking Rebif® since 2003

Annemarie — MS LifeLines® Field Nurse

— Annemarie, RN, BSN, MSCN

Annemarie has been a nurse for 20 years, working in hospital pediatrics as well as in long-term care, as a certified case manager. But it is the MS community that she believes is "one of the strongest, most caring I've ever encountered."

Annemarie has been an MS LifeLines Field Nurse for the past two years. In that time she says she has been inspired by the commitment of those who are truly dedicated to the MS community. Of course, she's inspired by the changes she sees in her patients, as well.

"My greatest reward," says Annemarie, "has been seeing patients after they've been on Rebif® (interferon beta-1a) for several months and they greet me with a smile and a hug!" This is, of course, a huge change from the way most people feel when they first meet Annemarie. "When I first meet people they tend to be scared and are especially concerned about side effects."

Two of her best pieces of advice for people starting Rebif therapy are to "drink lots of fluids and be patient!" She also suggests that people living with MS contact the MS Society and get involved. In Annemarie's words, "The more informed the patient, the better off they are."

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Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.