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"The best piece of advice that I've received to manage my MS is to take care of myself."

Shiela, MS LifeLines Ambassador

Living with RRMS since 2002

Taking Rebif® since 2003

Kelly — MS LifeLines® Field Nurse

— Kelly, RN, BSN

Kelly speaks from both professional and personal experience. She's not only been in nursing for 8 years (in a range of specialties including oncology, neonatal intensive care, and pain management), but her stepfather has MS.

"The greatest reward of working as an MS LifeLines Field Nurse has been the amount of quality time I get to spend with the patients. When I chose to become a nurse, I wanted to make a difference in people's lives, and being an MS LifeLines Field Nurse has allowed me to do this."

"I recently had an experience with a patient who was so afraid of injecting herself with a needle that she was shaking and crying while she held the syringe," says Kelly. "With patience and a lot of encouragement, she was able to inject. As soon as the needle went in, her face lit up. She couldn't believe she did it. She exuded confidence after her accomplishment."

The two most common questions Kelly says she's addressed with relapsing MS patients have been about dealing with side effects of Rebif® (interferon beta-1a) therapy and managing symptoms of MS. Kelly helps her patients with strategies for both.

When asked for the most helpful advice Kelly would give to a relapsing MS patient considering Rebif therapy, she had this to say, "Starting an effective therapy early on after diagnosis is the best chance at fighting this disease. Hang in there...it may be a bumpy road in the beginning, but it will all be worth it in the end because it will help you take control of your relapsing MS."

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Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.