"The best piece of advice that I've received to manage my MS is to take care of myself."
Shiela, MS LifeLines Ambassador
Living with RRMS since 2002
Taking Rebif® since 2003
Vision
Vision problems are not uncommon in people with MS. But they rarely result in total blindness.
Optic neuritis
is inflammation of the optic nerve. This is the nerve that transmits light and visual images from the eye to the brain. Approximately half of people with MS will have at least one episode of optic neuritis. Frequently, it is the first symptom of MS. Optic neuritis may result in blurring or graying of vision, or rarely, blindness in one eye. A dark spot may also occur in the center of the visual field.
Nystagmus
or uncontrolled horizontal or vertical eye movements, is another common symptom. Nystagmus may be mild, only occurring when the person looks to the side. Sometimes it may be severe enough to impair vision.
Double vision (diplopia)
occurs when the pair of muscles that control a
particular eye movement are weak. The muscles then become uncoordinated. When the images are not properly fused, the patient sees a double image. Double vision may increase with fatigue or overuse of the eyes.
Dealing with vision problems
The good news is that these vision problems are usually temporary. Patients generally recover. Steroid treatments may be useful for optic neuritis and nystagmus. Resting the eyes periodically throughout the day and/or wearing an eye patch can be helpful for double vision. Speak with your health care provider if you experience vision problems.
Brought to you by EMD Serono, Inc. and Pfizer Inc, the co-marketers of Rebif® (interferon beta-1a) in the US 
Prescribing Information - Medication Guide
This information is intended only for residents of the United States.
Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Efficacy has been established in controlled studies up to 2 years in duration. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.
Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.
Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.
The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.
MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.
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