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Relapsing multiple sclerosis (MS) therapy:
Rebif® (interferon beta-1a)

Choosing a therapy that's right for you

When you and your health care provider choose a disease-modifying drug (DMD) to treat your relapsing MS, you want to choose a multiple sclerosis therapy that allows you flexibility, has been proven effective and has a well-established safety profile.

Consider Rebif

With Rebif, you get more than an effective treatment and a well-established safety profile. You also get a relapsing MS treatment with product features designed for flexibility and support services that can help you start—and stay—on therapy.

Meet Rebif Rebidose

Rebif® Rebidose® (interferon beta-1a) is a preassembled, single-use autoinjector for taking Rebif.

Rebif Rebidose

  • No assembly required
  • Portable, goes where you go
  • Needle stays covered before and after injection process
  • Flexible dosing options (44 mcg and 22 mcg)

Rebif should be refrigerated (between 36°F and 46°F). Do not freeze. If refrigeration is not available, Rebif Rebidose can be stored at room temperature for up to 30 days away from heat and light.

If you are newly diagnosed, or are considering switching therapy, ask your doctor about Rebif and Rebif Rebidose as an option.

  • 86% of the patients who tried Rebif Rebidose said it was easy to use
  • 77% said it was easy to hold
  • 87% said they would be comfortable using it away from home

Do not try to give yourself injections at home until you understand and are comfortable with how to prepare your dose and give the injections.

*In this user trial, Rebif Rebidose was evaluated for 12 weeks by 109 patients with relapsing MS, who had previously taken Rebif using the prefilled syringes or the reusable Rebiject II® autoinjector.

Proven effective: Rebif is the only self-injected relapsing MS therapy that is proven to work across all 3 key treatment goals for MS, as shown in the 2-year PRISMS study. Rebif is proven to slow disability progression, reduce relapse rates, and reduce active brain lesions on the studied MRI measures*‡

The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

The 2-year PRISMS study included 560 people to see how they responded to Rebif 22 mcg or Rebif 44 mcg versus placebo, all given under the skin 3 times a week.

Prevention of Relapses and Disability by Interferon ß-1a Subcutaneously in Multiple Sclerosis.
*Refers to new lesions and total lesion burden or area as defined in the AAN and MS Council guidelines.
New or enlarging lesions detected with PD/T2-weighted MRI.

Well-established safety profile: You can feel confident that the well-established safety profile of Rebif is backed more than by 18 years of clinical trial and patient experience.

The safety and efficacy of treatment with Rebif beyond 2 years has not been established.

Important safety information

Rebif will not cure multiple sclerosis (MS) but it has been shown to decrease the number of flare-ups and slow the occurrence of some of the physical disability that is common in people with MS. Rebif can cause serious side effects, so before you start taking Rebif, you should talk with your doctor about the possible benefits of Rebif and its possible side effects to decide if Rebif is right for you.

Please see important safety information below and Rebif Medication Guide and Prescribing Information in the top of this website, and speak with your doctor for more information.

Administration options: Rebif offers product features designed for flexibility.

MS LifeLines Access Made Simple is introducing $0 co-pay for those eligible. Call MS LifeLines and speak with a member of the Financial Support Team to determine your eligibility.

If you have no insurance or are underinsured, you may receive Rebif for up to 1 year at no cost. Before the year ends, MS LifeLines will assess your eligibility for further assistance and help you continue to receive Rebif at the lowest cost available to you.

To speak with the Financial Support Team about whether you may be eligible for MS LifeLines Access Made Simple or one of the many other financial assistance programs available, call 1-877-447-3243 Monday through Friday, 8 AM to 8 PM ET and Saturdays from 9 AM to 5 PM ET.

Learn more about MS LifeLines Access Made Simple eligibility requirements.

Some limitations are required by law. People residing in certain states, as well as those covered by federal and state programs, may not be eligible for assistance. Program eligibility requirements and benefits subject to change and discontinuation at any time.

Pursuant to a letter issued by the United States Department of Health and Human Services dated 10/30/2013, qualified health plans (QHPs) are not considered federal health care programs. As such, members of QHPs are eligible to receive co-pay assistance through the MS LifeLines Access Made Simple program. EMD Serono reserves the right to change or discontinue co-pay assistance for QHPs at any time.

Nursing support: When you take Rebif, you're not alone. The MS LifeLines Nurses are a vast team of nurses who provide training and support. They can answer some questions you may have about relapsing MS and Rebif.

A dedicated team of MS-certified nurse specialists is available in many areas across the United States and can help you get started on Rebif by providing in-home injection training and more.

Learn more about the benefits of Rebif therapy for relapsing multiple sclerosis:

Remember, by choosing Rebif, you get more than just proven efficacy—you get product features and support designed to meet your individual needs.


Rebif® (interferon beta-1a) is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for treatment of chronic progressive MS.

Important safety information

What is the most important information I should know about Rebif?

Rebif will not cure multiple sclerosis (MS) but it has been shown to decrease the number of flare-ups and slow the occurrence of some of the physical disability that is common in people with MS. Rebif can cause serious side effects, so before you start taking Rebif, you should talk with your doctor about the possible benefits of Rebif and its possible side effects to decide if Rebif is right for you. Potential serious side effects include:

  • Depression. Some patients treated with interferons, including Rebif, have become seriously depressed (feeling sad). Some patients have thought about killing themselves and a few have committed suicide. Depression (a sinking of spirits or sadness) is not uncommon in people with multiple sclerosis. However, if you are feeling noticeably sadder or helpless, or feel like hurting yourself or others, you should tell a family member or friend right away and call your doctor as soon as possible. Your doctor may ask that you stop using Rebif. You should also tell your doctor if you have ever had any mental illness, including depression, and if you take any medications for depression
  • Liver problems. Your liver may be affected by taking Rebif and a few patients have developed severe liver injury. Your health care provider may ask you to have regular blood tests to make sure that your liver is working properly. If your skin or the whites of your eyes become yellow or if you are bruising easily you should call your doctor right away
  • Risk to pregnancy. If you become pregnant while taking Rebif you should call your doctor right away. Rebif may cause you to lose your baby (miscarry) or may cause harm to your unborn child. You and your doctor will need to decide whether the potential benefit of taking Rebif is greater than the risks are to your unborn child
  • Allergic reactions. Some patients taking Rebif have had severe allergic reactions leading to difficulty breathing and loss of consciousness. Allergic reactions can happen after your first dose or may not happen until after you have taken Rebif many times. Less severe allergic reactions, such as itching, flushing or skin bumps, can also happen at any time. If you think you are having an allergic reaction, stop using Rebif immediately and call your doctor
  • Injection-site problems. Rebif may cause redness, pain or swelling at the place where an injection was given. Some patients have developed skin infections or areas of severe skin damage (necrosis) requiring treatment by a doctor. If one of your injection sites becomes swollen and painful or the area looks infected and it doesn’t heal within a few days, you should call your doctor. For more information, please see Medication Guide

Who should not take Rebif?

Do not take Rebif if you:

  • Have had an allergic reaction, such as difficulty breathing, flushing, or hives, to another interferon beta or to human albumin

If you have any of the following conditions or serious medical problems, you should tell your doctor before taking Rebif:

  • Depression (a sinking feeling or sadness), anxiety (feeling uneasy or fearful for no reason), or trouble sleeping
  • Liver diseases
  • Problems with your thyroid gland
  • Blood problems, such as bleeding or bruising easily, and anemia (low red blood cells) or low white blood cells
  • Epilepsy
  • Are planning to become pregnant

Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other, causing serious side effects. Talk to your doctor before you take any new medicines.

What are the possible side effects of Rebif?

  • Flu-like symptoms (fever, chills, sweating, muscle aches and tiredness)
  • Skin reactions. Soreness, redness, pain, bruising, or swelling may occur at the place of injection
  • Depression and anxiety. Some patients taking interferons have become very depressed and/or anxious
  • Liver problems
  • Abdominal pain
  • Blood problems. You may have a drop in the levels of infection-fighting blood cells, red blood cells or cells that help to form blood clots. If the drop in levels is severe, it can lessen your ability to fight infections, make you feel tired or sluggish or cause you to bruise or bleed easily
  • Thyroid problems. Your thyroid function may change. Symptoms of changes in the function of your thyroid include feeling cold or hot all the time, change in your weight (gain or loss) without a change in your diet or amount of exercise you are getting
  • Severe allergic reactions. Allergic reactions are rare and may be associated with difficulty in breathing and loss of consciousness, which require immediate medical attention

Let your doctor know if you have any of these symptoms or feel sad, tired, hot or cold, or experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

Refer to the Instructions for Use that comes with the Rebif® Rebidose® (interferon beta-1a) autoinjector.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call

This information is not intended to replace discussions with your doctor. For additional information about Rebif, please consult the Prescribing Information and Medication Guide and talk to your doctor. You can also visit www.rebif.com or call toll-free 1-877-447-3243. Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. Speakers and MS LifeLines Ambassadors who participate in Talk MS or in live events are sponsored by EMD Serono, Inc. and Pfizer Inc. Rebif, Rebif Rebidose, Rebiject II, MS LifeLines, and the Rebif logo are registered trademarks of EMD Serono, Inc. or its affiliates.

Brought to you by EMD Serono, Inc. and Pfizer Inc, the co-marketers of Rebif in the US.

This information is intended only for residents of the United States.