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"Balance...a medication that works for you, a support system and a doctor you trust."

The Rebif Guide

Rebif And MS LifeLines®

Have you recently been diagnosed with relapsing MS and are looking to start treatment? Or have you been living with relapsing MS, are currently on therapy, and are considering changing treatments? Either way, you've come to the right place. This is your guide to Rebif® (interferon beta-1a).

A balanced approach to managing relapsing MS

Rebif is proven to significantly slow the progression of relapsing multiple sclerosis (MS). It has been available in the United States since 2002 and is currently the most prescribed treatment outside the United States for relapsing forms of MS.

MS LifeLines Nurses

Learn how they can help you with your Rebif therapy.

How safe and effective is your MS therapy?

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Rebiject II(R) autoinjector

Design for convenience and ease of use.

Learn More

Rebif:

  • Is proven to work on all 3 key disease measures in MS: progression of disability, frequency of relapses, and activity and area of brain lesions on magnetic resonance imaging (MRI)*
  • Is proven to reduce MRI* activity and relapses more than Avonex® (interferon beta-1a) 30 mcg once a week at 48 weeks in relapsing forms of MS (Rebif 44 mcg taken 3 times a week)
  • Has a safety profile supported by more than 12 years of worldwide patient and clinical trial experience
  • Has many features designed for convenience
    • Thinnest needle of any MS therapy
    • Simple starter pack with premeasured, prefilled doses
    • Rebiject II® auto-injector
    • 3-times weekly dosing
    • Room temperature storage up to 30 days

*The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

MS LifeLines: developed with the help of people living with MS, for people with MS

MS LifeLines is a community and support system developed with the help of people living with MS, for people with MS.

MS LifeLines can help you start and stay on Rebif therapy with injection training, reimbursement support, and counseling. But MS LifeLines goes beyond support services. Through MS LifeLines, you can connect with a community of people who are living well with relapsing MS. Because you don't really get MS, until you get MS.

MRI

An MRI (Magnetic Resonance Imaging) is a test that shows the advancement/presence of lesions on the brain, a common tool used in the assessment of the progression of the disease. Rebif has been proven effective in reducing MRI lesion activity and area.

The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

Learn more about MRI and Rebif.

Frequently Asked Questions (FAQs)

If you have a particular question about Rebif, are wondering how you're going to cope with MS, or are considering a change in therapy, you should speak with your doctor. In the meantime, please feel free to review our FAQs.

For More Information

You should always talk to your doctor about your care. And, you can also always talk to an experienced MS LifeLines specialist who will answer your questions. Call toll free at 1-877-447-3243 Monday through Friday, 8 am to 8 pm ET.

Avonex is a registered trademark of Biogen Idec.

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.