"Balance...a medication that works for you, a support system and a doctor you trust."

Treatment Routine

Rebif May Be Right For You

Rebif^® (interferon beta-1a) is meant to fit the lifestyles of people like you who want to manage their relapsing MS.

You inject it just three times a week

You can pick the days that work best with your schedule. Rebif injections should be taken on the same three days a week. Injections should be at least 48 hours apart. Many people choose to take their injections on Monday, Wednesday, and Friday so that they have injection free weekends. After you decide which three days work best for your lifestyle, stick with those to help make your injections part of your weekly routine. If you accidentally take more than your prescribed dose, call your doctor right away.

It's injected just under your skin

Rebif is given by subcutaneous (under the skin) injection, as opposed to intramuscular (into the muscle) injection. With Rebif, you only have to put the needle right beneath your skin, and Rebif now uses a 29-gauge needle — the thinnest of any MS therapy.

Designed for ease of use

Rebif comes ready to use, in pre-measured, pre-filled syringes that already contain the medicine and do not require needle assembly, so you don't have to worry about mixing any solutions before injection. You can store your Rebif at room temperature for up to 30 days.

If you're just starting on Rebif therapy, Rebif's Titration Pack includes pre-measured, pre-filled dosing in the amounts you'll need as you're building up to your full dosing level.

Planning ahead can help you reduce and manage reactions

Flu-like symptoms and injection-site reactions can occur with Rebif. With a little planning and guidance from your health care professional, you should be able to manage these symptoms.

Flu-like symptoms

These tend to be more obvious when you first start taking Rebif. Then they may taper off as your body becomes more accustomed to treatment.

Injection-site reactions

Swelling, redness, and irritation may occur at the injection site. Talk to your health care professional about how to minimize these reactions.

Rebif is provided to patients with a Medication Guide.

Patients should read the Medication Guide carefully before starting Rebif and each time a prescription is filled. It is also important to talk to your doctor or other health care provider on a regular basis.

A dedicated team of MS-certified nurses at MS LifeLines are available toll-free Monday through Friday, 8 AM to 10 PM Eastern time, at 1-877-44-REBIF (1-877-447-3243). The team at MS LifeLines can answer your questions about relapsing MS and your treatment options, and can help you with your Rebif therapy.

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif^® (interferon beta-1a) in the US

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

We were unable to find the email address you entered. Please try again.

Multiple Sclerosis - MS LifeLines