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Multiple Sclerosis - MS LifeLines

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I wish I could find a relapsing MS treatment that's right for me

Tips on Taking Rebif

Watch MS LifeLines Ambassadors as they answer questions about diagnosis, family and friends, lifestyle changes and managing their relapsing MS treatment.

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Tips On Taking Rebif® (interferon beta-1a)

Tip 1:

Apply a warm cloth or compress to the injection site after injecting.

Tip 2:

Bedtime injections are advised to allow you to sleep through many of the flu-like symptoms.

Tip 3:

Leave the air bubble in the syringe.

Tip 4:

Remove Rebif® (interferon beta-1a) from the refrigerator and bring to room temperature 1 to 4 hours before injecting.

Tip 5:

If you forget an injection, and it has been 48 hours since your last injection, take it as soon as you remember. Then, skip a day and take the next one. If it has been more then three days or you have taken the wrong dose, contact your doctor.

Tip 6:

Rotate your injection sites, moving between different areas of the arms, legs, abdomen, and buttocks. Do not inject in the same place twice in a row, and be sure to wait at least seven days before using a particular spot again. Refer to the diagram in the Medication Guide.

Tip 7:

If you are very thin, use only the thigh or the outer surface of the arm for injection. Refer to the diagram in the Medication Guide.

Tip 8:

Never mix Rebif with other drugs in the same syringe.

Tip 9:

Determine your own limits and plan your days to make maximum use of your energy.

Tip 10:

Many people with MS say they have to plan ahead more than they were used to doing in the past and that they have to change some of their activities and schedules. If fatigue is a problem, for example, several short rest periods each day may allow you to continue your usual routine, but at a slightly slower pace.

Tip 11:

Try to sleep fairly regular hours.

Tip 12:

Afternoon fatigue may benefit from a shift to an early work schedule or by a regular afternoon nap.

Tip 13:

There are medications on the market that may decrease fatigue — consult with your doctor.

Tip 14:

Follow a good diet with fiber added in the form of bran cereals, vegetables, and fruits. Bran is one of the cheapest and most easily available forms of natural laxatives. Prune or lemon juice, an orange, apple, or fig could be taken in the evening for someone on a morning schedule and in the morning for a person on an evening schedule — consult with your doctor.

Tip 15:

A regular exercise program or recreational sport you are able to do will benefit you in the long run by maintaining good physical condition. This does not mean terribly strenuous sports unless, of course, you are able to — consult with your doctor.

Tip 16:

Many people have found a regular swimming or yoga program helpful in maintaining muscle tone without becoming overly tired — consult with your doctor.

Tip 17:

Many MS Society chapters offer exercise programs, such as yoga, swimming and horseback riding. If there is no chapter in your area, other community groups may have beneficial programs — consult with your doctor.

Brought to you by EMD Serono, Inc. and Pfizer Inc, the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Efficacy has been established in controlled studies up to 2 years in duration. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II and MS LifeLines are registered trademarks and the Rebif logo is a trademark of EMD Serono, Inc. or its affiliates.

MS in Balance Your Life in Full is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2009 EMD Serono, Inc. All rights reserved.