I wish my relapsing MS therapy fit my lifestyle
Comparing Treatments
Benefits of choosing Rebif
Relapsing MS can affect people differently. So can the medications used to treat it.
A treatment may be right for one person, but it may not be the best choice for another. Talk to your doctor, and together you can decide if Rebif is right for you.
| |
Rebif®
(interferon beta-1a) |
Betaseron®
(interferon beta-1b) |
Copaxone®
(glatiramer acetate injection) |
Avonex®
(interferon beta-1a) |
Tysabri®
(natalizumab) |
| Dosing Frequency |
3 times per week |
Every other day |
Every day |
Once per week |
Every 4 weeks |
| Number of injections per year/Route of injection |
156
(under the skin) |
182
(under the skin) |
365
(under the skin) |
52
(into the muscle) |
N/A (monthly, hour long IV infusion at registered infusion center) |
| Store at room temperature |
Up to 30 days if refrigeration is unavailable |
As unmixed powder, until expiration* |
Up to
1 month |
Up to
7 days (prefilled syringe) Up to 30 days (vial) |
N/A |
| Materials Needed for 1 Month of Treatment |
12 prefilled, preassembled syringes |
14 vials of powder
14 diluent syringes
14 vial adapter/needle
assemblies |
30 prefilled, preassembled syringes |
4 vials of powder, 4 vials of diluent,
4 injection needles, 4 syringes,
4 Micro Pins®. Also available as
4 prefilled syringes (require assembly) |
Must be administered by medical professional |
| Prefilled, preassembled syringes |
YES |
NO |
YES |
YES |
N/A |
No conclusions regarding comparative safety or effectiveness of these products can be drawn from these data.
*After mixing, if not used immediately, the product should be used and refrigerated within three hours.
With Rebif, each injection requires 13 fewer steps than with Betaseron. With Rebif, you have 209 fewer injections per year than you would with Copaxone.
Order your Rebif Information Kit today!
Read frequently asked questions about comparing treatments.
Avonex is a registered trademark of Biogen Idec.
Betaseron is a registered trademark of Bayer HealthCare Pharmaceuticals.
Copaxone is a registered trademark of Teva Neuroscience, Inc.
Tysabri is a registered trademark of Elan Corporation, Inc.
Brought to you by EMD Serono, Inc. and Pfizer Inc, the co-marketers of Rebif® (interferon beta-1a) in the US 
Prescribing Information - Medication Guide
This information is intended only for residents of the United States.
Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Efficacy has been established in controlled studies up to 2 years in duration. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.
Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.
Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.
The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.
MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.
Rebif, Rebiject II and MS LifeLines are registered trademarks and the Rebif logo is a trademark of EMD Serono, Inc. or its affiliates.
MS in Balance Your Life in Full is a service mark of EMD Serono, Inc. or its affiliates.
Copyright 2009 EMD Serono, Inc. All rights reserved.