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"Balance...a medication that works for you, a support system and a doctor you trust."

Ease of Use

The Convenience and Ease of Rebiject II

Rebiject II® is an auto-injection tool for use only with the Rebif syringe and is available exclusively for Rebif® (interferon beta-1a) users. Rebiject II has many features designed for convenience, injection safety, and less discomfort; plus, you will never have to see the needle.

Rebif convenience, flexibility, and support

Rebif® (interferon beta-1a) has the thinnest needle of any therapy for relapsing MS

The Rebif needle is 15% thinner than other MS therapies.

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Rebiject II(R) autoinjector

Design for convenience and ease of use.

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If you're just starting on Rebif therapy, Rebif's Titration Pack includes pre-measured, pre-filled dosing in the amounts you'll need as you're building up to your full dosing level.

Rebif is the only DMD with 2 approved doses, so you and your health care provider can choose the dose that's right for you.

Rebif should be stored in the refrigerator. If you're away from a refrigerator, Rebif may be stored at or below room temperature (25ºC/77ºF) for up to 30 days away from heat and light.

Rebif support

MS LifeLines® offers ongoing education and support for people with relapsing MS on Rebif therapy, including:

  • MS LifeLines Nurse Educators— MS-certified nurses who will visit you in your home to help you with injection training, tips to manage Rebif side effects, and provide ongoing support and education across many parts of the United States. For those in other areas, home health agency nurses are available for injection-training as well
  • A dedicated team of MS-certified nurses at MS LifeLines are available toll-free Monday through Friday, 8 AM to 10 PM ET, at 1-877-44-REBIF (1-877-447-3243) who can answer your questions about relapsing MS and your treatment options, and help you with your Rebif therapy
  • MS LifeLines reimbursement information specialists who can help you with insurance and reimbursement for your Rebif therapy
  • Online videos and journals of MS LifeLines Ambassadors, offering personal stories and strategies from people living well with relapsing MS

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.