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"Balance...a medication that works for you, a support system and a doctor you trust."

Making Your Decision

Deciding which therapy is right for you

When considering a therapy, you may want to ask your doctor the following questions:

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  1. Has it been proven to modify all 3 key measures of MS disease activity: disability, relapses, and MRI brain lesion activity and area?
  2. Has it been proven to work better compared with another MS therapy in a head-to-head clinical study?
  3. Does it have a safety profile that is supported by long-term experience?
  4. Does it offer features that may make it easier to stay on therapy?

The exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

"Many people choose a therapy based on how often it is taken—but they don't ask why there's a difference in the dose and frequency of interferon products. The fact is, the dose of interferon and how often it is taken are shown to affect how well it works. In clinical studies, higher, more frequent doses of interferon beta have been shown to work better than lower, less frequent doses."

— Sylvia Lucas, MD Clinical Professor of Neurology at University of Washington Medical Center

"I would have appreciated the opportunity to sit down with someone and have them walk me through the therapy options and explain their similarities and differences. During the diagnosis I was handed information about 3 drug therapies and told to make a decision on which one I wanted to start. The entire decision was on my shoulders and I did not have enough information. I was overwhelmed, confused, and scared. It's important to have an effective therapy because I want to safely slow down the progression of my relapsing MS. It is important to me that what I put into my body be safe and effective."

— Tara, MS LifeLines Ambassador

This reflects the personal experience of one person, and others can be different. Results and experiences vary from patient to patient. It is best to contact your doctor to discuss what's best for you. Tara is an MS LifeLines Ambassador, and she has chosen to share her story with other people living with MS.

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.