Treatment Differences

Rebif offers flexibility and convenience

• The only interferon beta available in a prefilled, preassembled, and ready-to-use syringe, so no premixing or assembly is required
• The Rebiject^® II auto-injector can help make injections easier than with manual injection
• The 3-times weekly dosing schedule allows for injection-free weekends

Rebif has 209 fewer injections per year than Copaxone^® (glatiramer acetate injection)

Rebif is less than half the size of an Avonex^® needle

A 25-gauge, 1" needle for intramuscular injection may be substituted for the 23-gauge, 1½" needle by the prescribing physician, if deemed appropriate. The higher the gauge, the thinner the needle. Although needles are shown to scale, they are not actual size.

Redness, pain or swelling at the injection site can occur with any injectable treatment.

This quote reflects the personal experience of one person, and others can be different. Results and experiences vary from patient to patient. It is best to contact your doctor to discuss what's best for you. Mike is an MS LifeLines Ambassador and has chosen to share his story with other people living with MS.

How do interferon therapies differ?

What's the difference between interferon-beta therapies used to treat relapsing MS?

Each interferon-beta therapy differs by:

• Where it is given (injected under the skin or into the muscle)
• How much is given (high vs low dose)
• How often it is taken (frequency)

The benefits of higher dose, more frequent interferon therapy

Rebif 44 mcg is a high-dose, high-frequency interferon-beta therapy, while Avonex is a lower dose interferon beta therapy that is taken less frequently. The three-times-weekly injection schedule of Rebif maintains a constant level of interferon beta-1a in your body. With the once-weekly injection schedule of Avonex, the level of interferon beta-1a fades throughout the week and is gone from your body 3 days before your next injection.

Over an average of 64 weeks in the EVIDENCE study*, Rebif 44 mcg given 3 times a week was shown to work better when compared to Avonex 30 mcg given once a week for:

• Reducing brain lesion activity on MRI
• Preventing relapses over an average of 64 weeks

Rebif is the only therapy for relapsing MS that has been proven to work better than another therapy in a Class I Trial**.

Read more about the EVIDENCE study.

This reflects the personal experience of one person, and others can be different. Results and experiences vary from patient to patient. It is best to contact your doctor to discuss what's best for you. Gary is an MS LifeLines Ambassador, and he and Kathy have chosen to share his story with other people living with MS.

Please note that the exact correlation between MRI findings and the current or future clinical status of patients, including disability progression, is unknown.

Please see the Rebif Medication Guide and speak with your doctor for more information.

Avonex is a registered trademark of Biogen Idec.

Copaxone is a registered trademark of Teva Neuroscience, Inc.

Betaseron is a registered trademark of Bayer HealthCare Pharmaceuticals Inc.