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Types of MS

If you need support with your Rebif® (interferon beta-1a) therapy, we can help you either online:

Or on the phone, toll free: 1-877-447-3243

You may be surprised to hear that people experience different types of MS. But MS is different for everyone.

Relapsing MS

Approximately 85% of people with MS are diagnosed with a type of MS called relapsing-remitting MS (RRMS). In this type of MS, people have clearly defined periods when the disease gets worse. These periods are called relapses. Your health care provider may call them "attacks" or "exacerbations ."

A relapse is when old symptoms worsen or new ones appear. For a symptom to be called a relapse, it must last for more than 24 hours in the absence of fever and be in some way disabling to you. Relapses may occur at any time, usually without warning, and can be mild or severe. In RRMS, relapses are followed by a long or short period of time when symptoms completely or partially go away. This is called remission .

In RRMS, relapses are followed by periods of remission. Over time disability accumulates.

Secondary-progressive MS

Another type of MS is secondary-progressive MS (SPMS). Some studies have estimated that without disease-modifying drugs (DMDs), one third to one half of people with RRMS would go on to develop SPMS 10 years after diagnosis. In SPMS, symptoms and permanent disability get progressively worse. Distinct relapses are less common, and remission periods are minor.

In SPMS, symptoms and disability get progressively worse. Relapses and periods of remission are less common.

Unfortunately, it is impossible for your health care provider to predict if and when you will go on to develop SPMS. The good news is that disease-modifying therapy may delay the development of SPMS.

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II, and MS LifeLines are registered trademarks of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.